Observe Intently (one)lumefantrine will lower the level or influence of exemestane by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. For sufferers getting exemestane with a potent CYP3A4 inducer the advised dose of exemestane is fifty mg day-to-day after a food.larotrectinib will boost the level or outcome of exe